Human Intestinal Microbiome and In Vivo Animal Models

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Hüseyin Hatipoğlu Mehmet Köroğlu


Studies related to microbiota have increased enormously with the introduction of the next generation squencing technology. Results of these studies have revealed the details of the interaction between the human body and its gut microbiota and the many mysterious and undefi ned topics. It is determined that gut microbiota is not stable, and it adapts to some factors in hours such as daytime diet, drug use (especially antibiotics).

One of the methods used for better understanding of this dynamic structure of microbiota and human-gut microbiota interaction is animal models. Animal models offer several advantages in terms of the tractability of microbiota. Many different animal models are suitable for such studies. In this respect, the role of microbiota on human metabolism can be determined more clearly. Steriled and gnotobiotic animal models can be designed to include even from a single microbiota member and to all microbiota members.

Almost all of the microbiota studies are concentrated on bacteria. Since viruses, parasites and fungi are also covered by microbiota, animal models should be developed for such microorganisms. By this way, other mysterious topics areas will also be revealed.

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How to Cite
HATIPOĞLU, Hüseyin; KÖROĞLU, Mehmet. Human Intestinal Microbiome and In Vivo Animal Models. Journal of Biotechnology and Strategic Health Research, [S.l.], v. 1, p. 148-156, dec. 2017. Available at: <>. Date accessed: 23 feb. 2019.