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Fecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium diffi cile infection. Promising fi ndings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Fecal microbiota transplantation (FMT) consists of the infusion of feces from a healthy donor to the GI tract of a recipient patient, in order to treat a specifi c disease associated with alteration of gut microbiota. There are still many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, methodology, long-term safety, and regulatory issues.