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In recent years, microbiomic and microbiota terms are frequently used. Relationship between microorganisms and the host can be studied by microbiomic studies. It was aimed to determine by human microbiology project initiated with 300 volunteers in 2007 and to investigate whether human microbiomic changes can be related to diseases. Just like genomics, the number of microorganisms in the human body is 10 times higher than the number of human cells. That is, a human is a holobiont (super organism) consisting of a combination of 10% human and 90% microbial cells.
Human microbiota consist of viruses, fungi and many eukaryotic microorganisms, especially bacteria, In addition, the bacterial genome in the human body is 150 times more than the human genome.
Most of the human microbiota is colonized in the gut, genitourinary system and respiratory system, especially in the digestive system. The colon alone contains more than 70% of the microorganisms in our body.
Microbiota has an important role in human, illness and health. In this case, microbiota can be thought of as an obscured organ. Primarily the intestinal microbiota, provide the necessary signals by promoting immune cell maturation and normal development of immune system functions. Research in microbiota have opened a new page in rheumatology.
In recent years, the microbiota structure of the intestines, urogenital, and respiratory tracts has become more understandable in relation to infl ammatory rheumatic diseases